چکیده (انگلیسی):

Objective: To identify whether Canova medication changes TNF-a and IL-10 serum
levels in mice infected with Trypanosoma cruzi Y strain.
Methods: Animals were divided into five groups: non-treated infected animals (I);
benznidazole-treated infected animals (Bz; 100 mg/kg body weight, single daily dose by
gavage); Canova medication (CM) treated infected animals (CM; 0.2 mL/animal, single
daily dose by gavage); benznidazole- and Canova medication-treated infected animals
with the above-mentioned dose (Bz+CM); and non-infected animals (C). TNF-a and IL-
10 levels were determined in serum aliquots after 4, 7, 10, 13, and 29 days of infection.
An ELISA technique was employed with R&D System Inc. antibody pairs.
Results: A high increase in TNF-a and IL-10 levels occurred in the infected and CMtreated
groups within the treatment employed on the 10th day after infection, coupled
with a IL-10 decrease on the 13th day after infection when compared with the other
experimental groups.
Conclusions: CM may change the balance between plasma cytokine levels (TNF-a and
IL-10) in mice infected with Y strain T. cruzi, with important consequences leading towards
a more severe infection.