چکیده (انگلیسی):

Objective: To investigate the effects of exogenous recombinant human brain natriuretic
peptide (rhBNP) after primary percutaneous coronary intervention (PCI) on non-invasive
hemodynamic in acute myocardial infarction patients with left ventricular failure.
Methods: A number of 96 acute myocardial infarction patients accompanied with heart
failure after PCI hospitalized in the People's Hospital of Sanya during February 2012 to
October 2015 were selected. They were randomly divided into the therapy group (n = 50)
and control group (n = 46). On the basis of routine treatment, patients in the therapy
group were treated with intravenous rhBNP (1.5 mg/kg was intravenous injection with
uniform speed of 3 min, followed by continuous infusion 0.007 5 mg/kg$min for 72 h),
while the control group received conventional treatment. BioZ-2011 non-invasive hemodynamic
real-time monitoring system was used to monitor the hemodynamic parameters
changes and the leaves of plasma pro-BNP, serum creatinine, serum potassium,
serum sodium and urine volume of each group before and after treating for 30 min, 1 h,
3 h, 6 h, 12 h, 24 h, 48 h, 72 h.
Results: Patients in the therapy group showed no effect on heart rate, while after 30 min
of intravenous injection of rhBNP, CO, CI, SV, and SI increased significantly and LVET
and TFC reduced at the same time, which had certain effect on blood pressure (SBP/
DBP). Compared with the control group, the therapy group showed a faster and more
effective improvement on hemodynamics.
Conclusions: Acute myocardial infarction patients complicated with left heart failure
after primary PCI can significantly improve hemodynamics by treating with rhBNP.