چکیده (انگلیسی):

Objective: To study the effect of Alpinia officinarum Hance (A. officinarum) 80%
alcohol extract on the primary dysmenorrhea.
Methods: A. officinarum 80% alcohol extract were enriched by macroporous adsorption
resins. Female mice of primary dysmenorrhea model were established by oxytocin induction;
the effects of A. officinarum 80% alcohol extract on primary dysmenorrhea were
observed by body twist method; and the homogenate level of prostaglandin F2a (PGF2a),
prostaglandin E2 (PGE2) and Ca2+ in the uterus were observed in oxytocin-induced female
mice.
Results: The writhing frequency of primary dysmenorrhea mice was significantly
decreased after treatment of A. officinarum 80% alcohol extract and the level of PGF2a,
PGE2 and Ca2+ in mice uterus was significantly decreased (P < 0.05, P < 0.01) in groups
of mice treated with middle and high dosage of A. officinarum 80% alcohol extract
compared with that of model group.
Conclusions: These findings suggest that A. Officinarum 80% alcohol extract can
significantly relieve primary dysmenorrhea.