چکیده (انگلیسی):

The effects of hydroalcoholic extract of Peganum harmala seeds (EPS) on
spontaneous rhythmic contractions of isolated rat uterine was investigated in this
study. EPS was tested on the isolated uterus and endometrium free (i.e. stripped
myometrium) preparations. EPS was found to exhibit significant spontaneous
contractions of the uterus and stripped myometrium relative to the solvent control.
After recording the pattern of uterus tissue spontaneous motility, in order to
determine mechanism of EPS pharmacological effects, atropine, indomethacin, or
prazocin was added into the organ baths. Pretreatment with atropine (70 nM) in both
the whole uterus and in the stripped myometrium preparations had no effects on the
response to cumulative dosage of EPS. Calcium-free solution decreased the uterus
contractions. In calcium dose-response curves, EPS in some concentrations produced
uterotonic effect in calcium-free solution in the presence of KCl. This finding
showed that EPS may increase calcium influx through voltage-dependant calcium
channels.