چکیده (انگلیسی):

Objective: In this paper, we will discuss if the CETP polymorphism contributes to the
centenarians in Hainan island.
Methods: We tested the TaqIB and I405V polymorphisms of CETP gene among 276
centenarians and 301 matched healthy individuals by AS-PCR and analyzed the data with
SPSS software package (Version 19.0).
Results: Our data indicated that allele B1 and V have the significant differences between
centenarians and healthy control groups with P < 0.001. Further analysis implied that
genotypes B1B1 (P < 0.001, OR = 0.148, 95% CI = 0.095–0.230) and VV (P < 0.001
and OR = 0.353, 95% CI = 0.237–0.525) were significantly different between centenarians
and matched controls. The combination of B and V, such as B1B1-II (P < 0.001,
OR = 0.128, 95% CI = 0.049–0.329), B1B1-IV (P < 0.001, OR = 0.115, 95%
CI = 0.056–0.237), B1B2-VV (P < 0.05, OR = 0.534, 95% CI = 0.310–0.920), and
B2B2-VV (P < 0.001, OR = 0.198, 95% CI = 0.086–0.453) have significant differences
between centenarians and matched healthy individuals from Hainan.
Conclusion: Our results implied that allele B1B1 and VV, as well as the combination
B1B1-II, B1B1-IV, B1B2-VV and B2B2-VV may contribute to the longevity in centenarians
of Hainan, south of China