چکیده (انگلیسی):

Background: Limited information is available regarding the clinical usefulness of measuring the levels of
IgE to allergen components from house dust mites (HDMs) in the diagnosis of genuine HDM allergy.
Methods: To evaluate the diagnostic usefulness of measuring levels of serum IgE antibodies (Abs) to
allergen components from Dermatophagoides pteronyssinus (DP) as a predictor of immediate asthmatic
response (IAR) to bronchoprovocation, we studied 55 DP-sensitized asthmatic patients who underwent a
bronchoprovocation test using crude DP extract. The levels of IgE Abs to crude DP, nDer p 1, rDer p 2, and
rDer p 10 in patients who showed IAR (n ¼ 41) were compared with those in patients who showed no
IAR (n ¼ 14).
Results: While the frequencies of positivity for IgE Abs to nDer p 1 and rDer p 2 among the entire study
population were 89 and 86%, respectively, all patients with IAR tested positive for both of them with high
IgE concentrations. The areas under the receiver operating characteristic curves for IgE to nDer p 1 and
rDer p 2 as predictors of IAR were 0.913 and 0.906, respectively. The specificity of IgE to nDer p 1 and
rDer p 2 was higher than IgE to crude DP even at low cut-off points.
Conclusions: IgE to nDer p 1 and/or rDer p 2 was highly predictive of allergen-induced IAR. These
findings validate the clinical usefulness of measuring the levels of IgE to nDer p 1 and rDer p 2 as a
diagnostic tool for genuine HDM allergy.