چکیده (انگلیسی):

Group 2 innate lymphoid cells (ILC2s) are recently identified cell populations that produce type 2 cytokines
such as IL-5 and IL-13 in response to epithelial cell-derived cytokines. Although ILC2s were
initially reported to play a key role in the anti-helminth innate immunity, we now have greater interest
in their role in asthma and other allergic diseases. In various asthma mouse models, ILC2s provoke
eosinophilic inflammation accompanied by airway hyperresponsiveness independent of acquired immunity.
Moreover, recent mouse studies show that ILC2s also promote acquired immunity and Th2
polarization, and various cytokines and lipid mediators influence the functions of ILC2s. Although ILC2s
have also been identified in humans, studies on the role of human ILC2s in asthma are very limited. Thus
far, human studies have shown that there is a slight difference in responsiveness and production of
cytokines between mouse and human ILC2s, and it has been suggested that ILC2s are involved in allergictype
asthma and the exacerbation of asthma. In this review, we focus on mouse and human ILC2s, and
discuss their role in asthma.