چکیده (انگلیسی):

Thrombotic thrombocytopenic purpura (TTP) is a multisystem disorder characterized by
microvascular aggregation of platelets and fibrin strands causing thrombocytopenia, microangiopathic
hemolytic anemia, and organ dysfunction. TTP can develop as a result of a deficiency
in ADAMTS13 enzyme activity due to either a genetic defect or, more commonly, the development
of anti-ADAMTS13 autoantibodies. TTP can also be associated with pregnancy, organ
transplant, lupus, infections, and drugs. Here, we present a case of TTP that developed shortly
after the start of clopidogrel treatment for acute ischemic stroke and acute myocardial infarction,
and describe the clinical presentation, refractory course of the disease, and successful
induction of remission through the use of rituximab in a setting of pre-existing autoimmune diseases.

2015 King Faisal Specialist Hospital & Research Centre. Published by Elsevier Ltd. This is an
open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-ncnd/
4.0/).