چکیده (انگلیسی):

The purpose of the present study was to develop intranasal
delivery systems of sumatriptan using thermoreversible
polymer Pluronic F127 (PF127) and mucoadhesive polymer
Carbopol 934P (C934P). Formulations were modulated
so as to have gelation temperature below 34°C to ensure
gelation at physiological temperature after intranasal administration.
Gelation temperature was determined by physical
appearance as well as by rheological measurement. The gelation
temperatures of the formulations decreased by addition
of increasing concentrations of Carbopol (ie, from 29°C
for 18% PF127 to 23.9°C for 18% PF127, 0.5% Carbopol).
The mucoadhesive force in terms of detachment stress, determined
using sheep nasal mucosal membrane, increased
with increasing concentration of Carbopol. The results of in
vitro drug permeation studies across sheep nasal mucosa indicate
that effective permeation coefficient could be significantly
increased by using in situ gelling formulation with
Carbopol concentration 0.3% or greater. Finally, histopathological
examination did not detect any damage during in
vitro permeation studies. In conclusion, the PF127 gel formulation
of sumatriptan with in situ gelling and mucoadhesive
properties with increased permeation rate is promising for
prolonging nasal residence time and thereby nasal absorption