چکیده (انگلیسی):

Background: Intra individual longitudinal data has been lacking for IgE-mediated seasonal allergic rhinitis
(SAR), especially in young children. Little is known about the development and natural course of SAR in terms
of prevalence and incidence rates in schoolchildren.
Methods: In May or June each year from 1994 to 2007, schoolchildren were assessed for serum Japanese
cedar pollen (JCP)-IgE and house dust mite (HDM)-IgE levels, and surveyed regarding nasal symptoms.
Results: Among the 220 children initially assessed in the first grade, 69 (31.4%) were already sensitized to
JCP at first grade and 119 (54.1%) did not develop JCP sensitivity during the 6-year study at all. In the first
grade children who were HDM-sensitized but JCP non-sensitized, JCP-IgE level was significantly elevated
compared to the JCP and HDM non-sensitized group. This seems to indicate that HDM sensitization was very
strongly associated with JCP sensitization.
Conclusions: Elevated serum IgE is a consequence of specific sensitization to HDM and HDM sensitization
appeared to develop prior to the start of primary school which distinguishes HDM sensitization from JCP sensitization.