چکیده (انگلیسی):

Background/Objective: As renal transplantation may increase survival rates and
improve quality of life for children with end-stage renal disease, we investigated the longterm
outcomes and prognostic factors of pediatric renal transplantation.
Methods: A retrospective study was conducted to review 25 pediatric renal transplantations,
either from live or deceased donors, in our hospital from 1995 to 2008. The cumulative graft
survival rate was calculated using the Kaplan-Meier method. Log rank tests were employed
to identify categorical prognostic factors for graft survival of the pediatric renal transplantations,
and Cox regression analysis for numeric factors.
Results: The mean age of our study subjects was 11.63
3.76 years, and the mean follow-up
period was 49.24
33.72 months. The 12-month and 36-month graft survival rates were 92%
and 82.14%, respectively. The rejection-free survival rates were 88% and 72.88% in the first
and third years, respectively. All of the patients were alive during the follow-up period. Acute
rejection (p Z 0.0175) and male sex (p Z 0.0384) were found to be significant factors for graft
survival.
Conclusion: For pediatric patients, we found that renal transplantation is now a safe and
effective surgical procedure for children with end-stage renal disease. Acute rejection and
male gender were identified as prognostic factors for poor graft survival.