چکیده (انگلیسی):

Background: Current in vitro fertilization (IVF) methods can't predict oocyte quality
after oocyte retrieval. Anti-Mullerian hormones (AMH) in the follicular fluid are produced
directly by granulosa cells therefore should be considered as parameter for predicting
oocyte quality. The objective of this study is to develop a non-invasive method for
predicting oocyte quality.
Methods: This is a prognostic study with a cross sectional design, conducted from April
2012 to June 2013 at Yasmin IVF Clinic – Dr. Cipto Mangunkusumo General Hospital
Jakarta. The subjects of this study were infertile couples underwent IVF. The measurement
of serum AMH and estradiol level was performed at the beginning of IVF cycles,
while follicular fluid AMH, were measured on the day of oocytes retrieval. Oocyte quality
was measured using Xia morphology criteria.
Result: We obtained 102 IVF patients with antagonist protocol. Serum and follicular
fluid AMH, serum estradiol, number of mature oocytes, and oocytes morphological score
were assessed. Serum AMH, follicular fluid AMH and serum estradiol were related to
oocytes quality. Based on the multivariate analysis, we found that age and serum AMH
level are the best two predictors for oocyte quality.
Conclusion: Serum AMH, but not the follicular AMH, can be used to predict oocytes
quality.