چکیده (انگلیسی):

The number of particulate delivery systems for biologics is negligible compared to liquid
dosage forms, signifying the complications associated with development of solid protein
delivery systems. Particulate protein delivery systems can improve stability, reduce viscosity
of suspensions at high protein concentration and allow for controlled drug release. This
review discusses current advances in controlled delivery of particulate protein formulations.
While the focus lies on protein crystals and delivery systems employing protein crystals,
amorphous protein particles will also be addressed. Crystallization and precipitations methods
and modifications allowing controlled delivery with and without encapsulation are summarized
and discussed.