چکیده (انگلیسی):

Gastric cancer (GC) is a common cancer affecting patients around the world. The pathogenesis of gastric
cancer has not been understood completely. Genetic mutations and the inflammation induced by Helicobacter
pylori (HP) seem to play important roles. The cytokine Interleukin-4 (IL-4) has effects in
inflammation, allergies and cancer including GC. The association of IL-4 -590 C>T polymorphism and
gastric cancer has been studied in different populations with inconsistent results. Here, we report this
meta-analysis showing that the polymorphism of IL-4 -590C>T might not be associated with the GC
susceptibility in both Asian and Caucasian populations.