چکیده (انگلیسی):

Advanced drug delivery systems using poly(ethylene glycol) (PEG) is an important development
in anti-cancer therapy. PEGylation has the ability to enhance the retention time of
the therapeutics like proteins, enzymes small molecular drugs, liposomes and nanoparticles
by protecting them against various degrading mechanisms active inside a tissue or cell, which
consequently improves their therapeutic potential. PEGylation effectively alters the pharmacokinetics
(PK) of a variety of drugs and dramatically improves the pharmaceutical values;
recent development of which includes fabrication of stimuli-sensitive polymers/smart polymers
and polymeric micelles to cope of with the pathophysiological environment of targeted
site with less toxic effects and more effectiveness. This overview discusses PEGylation involving
proteins, enzymes, low molecular weight drugs, liposomes and nanoparticles that
has been developed, clinically tried for anti-cancer therapy during the last decade.