چکیده (انگلیسی):

Prostanoids, which include prostaglandin and thromboxane, are metabolites of arachidonic acid released
in various pathophysiological conditions. They induce a range of actions mediated through their
respective receptors expressed on target cells. It has been demonstrated that each prostanoid receptor
has multiple functions and that the effect of receptor stimulation can vary depending on context; this
sometimes results in opposing effects, such as simultaneous excitatory and inhibitory outcomes. The
balance between the production of each prostanoid and the expression of its receptors has been shown
to be important for maintaining homeostasis but also involved in the development of various pathological
conditions such as allergy. Here, we review the recent findings on the roles of prostanoids in
allergy, especially focusing on atopic dermatitis and asthma.