نقش پاتوژن مستقیم و غیر مستقیم اتوآنتی بادی در بیماری های خود ایمنی سیستمیک
Direct and Indirect Pathogenic Roles of Autoantibodies in Systemic Autoimmune Diseases
نویسندگان |
این بخش تنها برای اعضا قابل مشاهده است ورودعضویت |
اطلاعات مجله |
Allergology International. |
سال انتشار |
2014 |
فرمت فایل |
PDF |
کد مقاله |
9043 |
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چکیده (انگلیسی):
Autoantibody (autoAb) production in patients with systemic autoimmune diseases is a hallmark of disease entity,
activity and prognosis. Although a large number of autoAbs have been discovered to date, there is a limited
number of autoAbs whose pathogenic roles have been clearly determined. However, intriguing evidence has
recently been provided of possible pathogenic roles for anti-neutrophil cytoplasmic Abs (ANCAs) against
myeloperoxidase (MPO) in ANCA-associated vasculitides (AAV) and for anti-citrullinated protein Abs (ACPAs)
in rheumatoid arthritis (RA). Of note, these autoAbs are thought to display both direct and indirect effects on organ
failure. Additionally, some autoAbs have been reported to play pathogenic roles in brain damage in patients
with neuropsychiatric systemic lupus erythematosus (NPSLE), which is one of the most refractory autoimmune
disorders. Thus the binding of autoAbs to a certain sequence of the N-methyl-D-aspartate receptor
subunit NR2 (anti-NR2 Abs) may directly induce hippocampal neuronal injury. On the other hand, anti-U1 ribonucleoprotein
(RNP) Abs might be pathogenic by inducing neurotoxic inflammatory mediators intrathecally.
Such autoAb measurements are also clinically meaningful for treatment selection.
کلمات کلیدی مقاله (فارسی):
آنتی بادی های نوتروفیل سیتوپلاسمی، اتوآنتی بادی، RA، SLE، واسکولیت
کلمات کلیدی مقاله (انگلیسی):
anti-neutrophil cytoplasmic antibodies, autoantibodies, RA, SLE, vasculitis
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