چکیده (انگلیسی):

The purpose of this review is to discuss and summarize
some of the interesting findings and applications of cyclodextrins
(CDs) and their derivatives in different areas of
drug delivery, particularly in protein and peptide drug
delivery and gene delivery. The article highlights important
CD applications in the design of various novel delivery
systems like liposomes, microspheres, microcapsules, and
nanoparticles. In addition to their well-known effects on
drug solubility and dissolution, bioavailability, safety, and
stability, their use as excipients in drug formulation are also
discussed in this article. The article also focuses on various
factors influencing inclusion complex formation because an
understanding of the same is necessary for proper handling
of these versatile materials. Some important considerations
in selecting CDs in drug formulation such as their commercial
availability, regulatory status, and patent status are
also summarized. CDs, because of their continuing ability
to find several novel applications in drug delivery, are expected
to solve many problems associated with the delivery
of different novel drugs through different delivery routes.