چکیده (انگلیسی):

The aim of the present study was to investigate the potential
of a nanoemulsion formulation for transdermal delivery of
aceclofenac. Various oil-in-water nanoemulsions were prepared
by the spontaneous emulsification method. The nanoemulsion
area was identified by constructing pseudoternary
phase diagrams. The prepared nanoemulsions were subjected
to different thermodynamic stability tests. The nanoemulsion
formulations that passed thermodynamic stability tests were
characterized for viscosity, droplet size, transmission electron
microscopy, and refractive index. Transdermal permeation of
aceclofenac through rat abdominal skin was determined by
Franz diffusion cell. The in vitro skin permeation profile of
optimized formulations was compared with that of aceclofenac
conventional gel and nanoemulsion gel. A significant
increase in permeability parameters such as steady-state flux
(Jss), permeability coefficient (Kp), and enhancement ratio
(Er) was observed in optimized nanoemulsion formulation
F1, which consisted of 2% wt/wt of aceclofenac, 10% wt/wt
of Labrafil®, 5% wt/wt of Triacetin®, 35.33% wt/wt of
Tween 80®, 17.66% wt/wt of Transcutol P®, and 32% wt/wt
of distilled water. The anti-inflammatory effects of formulation
F1 showed a significant increase (P G .05) in percent
inhibition value after 24 hours when compared with aceclofenac
conventional gel and nanoemulsion gel on carrageenaninduced
paw edema in rats. These results suggested that
nanoemulsions are potential vehicles for improved transdermal
delivery of aceclofenac.