چکیده (انگلیسی):

The conversion of aqueous dispersion of nanostructured lipid carriers (NLCs) into dry powder
by spray drying could be a useful approach to render NLCs with better physical chemical
stability than the aqueous dispersion. In this study, aqueous NLC dispersion containing
fenofibrate was converted into dry, easily reconstitutable powder using spray drying.A central
composite face centered design (CCFD) was used to investigate the influence of the ratio
of lipid to protectant (mannitol and trehalose) and crystallinity of spray-dried powder on
the particle size, yield and residual moisture content of the dried powder. A linear relationship
(R2 = 0.9915) was established between the crystalline content of the spray-dried
powders against the ratio of mannitol to trehalose from 3:7 to 10:0 (w/w). Spray drying of
NLC aqueous dispersion using a mannitol and trehalose mixture resulted in an increase
in particle size of the NLCs after reconstitution in water as compared to that in the initial
aqueous dispersion. The decrease in crystallinity of the dry powder by reducing the ratio
of mannitol to trehalose could improve the reconstitution of the NLCs in water. However
the yield and residual moisture content of dry powder decreased with an increase in the
ratio of mannitol to trehalose. Lipid nanoparticles were able to retain the drug incorporation
and the prolonged drug release profile after spray drying. The experimental model was
robust, and suggested that spray drying is a viable technique for the conversion of NLCs
into dry powder.