چکیده (انگلیسی):

Objective: To investigate the differential of protein expression in CCl4 induced mice treated
with lycorine. Methods: The present study was carried out to identify the differentially
expressed protein in carbon tetrachloride (CCl4) induced oxidative stress mice treated with
lycorine (5 mg/kg. bw) using 2D gel and MALDI-TOF. Results: We observed many kinds of
differentially expressed protein in experimental liver. Among these, three are much differently
expressed protein which is identified as ATP synthase, regucalcin and HSP60; these proteins
are involved in the ATP synthesis, calcium regulation and rescue the integrity cellular proteins
respectively. Conclusion: This investigation provided a molecular mechanism of the lycorine
during CCl4 induced oxidative stress in mice liver.