چکیده (انگلیسی):

Cannabis sativa has long been known for its psychotropic effect. Only recently with the
discovery of the cannabinoid receptors, their endogenous legends and the enzymes
responsible for their synthesis and degradation, the role of this ‘endocannabinoid system’
in different pathophysiologic processes is beginning to be delineated. There is evidence
that CB1 receptor stimulation with synthetic cannabinoids or Cannabis sativa extracts
rich in D9-tetrahydrocannabinol inhibit gastric acid secretion in humans and experimental
animals. This is specially seen when gastric acid secretion is stimulated by pentagastrin,
carbachol or 2-deoxy-D-glucose. Cannabis and/or cannabinoids protect the gastric mucosa
against noxious challenge with non-steroidal anti-inflammatory drugs, ethanol as
well as against stress-induced mucosal damage. Cannabis/cannabinoids might protect the
gastric mucosa by virtue of its antisecretory, antioxidant, anti-inflammatory, and vasodilator
properties.