چکیده (انگلیسی):

Background: The vast majority of abdominal aortic aneurysms found in screening programs are small,
and as no effective treatment exits, many will expand until surgery is indicated. Therefore, it remains
intriguing to develop a safe and low cost treatment of these small aneurysms, that is able to prevent or
delay their expansion.
In this study, we investigated whether intraluminal delivered pentagalloyl glucose (PGG) can impair the
early AAA development in a porcine model.
Methods: The infrarenal aorta was exposed in thirty pigs. Twenty underwent an elastase based AAA
inducing procedure and ten of these received an additional intraluminal PGG infusion. The final 10 were
sham operated and served as controls.
Results: All pigs who only had an elastase infusion developed macroscopically expanding AAAs. In pigs
treated with an additional PGG infusion the growth rate of the AP-diameter rapidly returned to physiological
values as seen in the control group. In the elastase group, histology revealed more or less
complete resolution of the elastic lamellae in the media while they were more abundant, coherent and
structurally organized in the PGG group. The control group displayed normal physiological growth and
histology.
Conclusion: In our model, intraluminal delivered PGG is able to penetrate the aortic wall from the inside
and impair the early AAA development by stabilizing the elastic lamellae and preserving their integrity.
The principle holds a high clinical potential if it can be translated to human conditions, since it, if so,
potentially could represent a new drug for stabilizing small abdominal aneurysms.