چکیده (انگلیسی):

Polyoxometalates (POMs) have become very significant in biomedical research for their
structural diversity which renders them highly active against bacterial, viral and cancer
diseases. In this study three different POMs were synthesized and nanoassemblies
were made with chitosan (CTS), a natural biodegradable polymer with excellent drug carrier
properties. The compounds were tested on two isoenzymes of alkaline phosphatases
including tissue specific calf intestine alkaline phosphatase (CIAP) and tissue non-specific
alkaline phosphatase (TNAP). Compound [TeW6O24]6− (TeW6) showed the highest activity
(45.4
±
11.3 nM) among tested compounds against TNAP. Similarly, chitosan-[TeW6O24]6−
(CTS-TeW6) was proved to be a potent inhibitor of CIAP with Ki value of 22
±
7 nM. A comparative
study was made to evaluate their cytotoxic potential against HeLa cells. Among
all tested compounds, Chitosan-[NaP5W30O110]14− (CTS-P5W30) has showed higher percent
cytotoxicity (88
±
10%) at 10 M when compared with the standard anticancer drug
vincristine (72
±
7%). The study revealed that selected POMs proved excellent anticancer
potential and were equally effective against alkaline phosphatase enzyme, an increased
level of which may indicate cancer metastasis.