چکیده (انگلیسی):

The purpose of present study was to evaluate commercial preparations of carbamazepine
tablets with respect to drug release through a defined sequence of experiments using Minitab software.
The compliance of products with respect to United States Pharmacopeia (USP) dissolution test and
comparison of the products with respect to drug release in different dissolution conditions is reported in
the present paper. The different dissolution conditions studied include dissolution medium (1% SLS in
purified water, 0.1 N HCl), volume (900 and 1,000 ml), rpm (50 rpm, 75 rpm). Studies indicated that all
six products complied with USP dissolution criteria. However, the extent of influence of dissolution
conditions on drug release was varied among the products. Distinct dissolution profiles were observed
and there was no correlation with disintegration time in certain products. The in vitro dissolution
experimentation helped in identifying the discriminatory dissolution conditions and also the formulations
that were unaffected with change of dissolution variables. In summary, commercial preparations of
carbamazepine vary widely in their dissolution behavior inmulti dissolution run experimentation. Identifying
this behavior of the products was essential as an in vitro tool for screening a good and a bad formulation.