چکیده (انگلیسی):

Among the numerous chemicals discharged into the surrounding environment, bisphenol
A (BPA) and octylphenol (OP) have been shown to increase oxidative stress in body by
disturbing the prooxidant/antioxidant balance of cells. Cinnamon aqueous extract (CAE)
is a natural product rich in polyphenolic compounds that have antioxidant activity. This
study was designed to investigate the protective efficacy of CAE against oxidative disorders
induced by BPA and OP in male albino rats. Animals were divided into 6 groups (10
rats each) and treated orally, 3 times weekly for 50 days. Group 1: control vehicle (olive
oil); group 2 (25 mg BPA/kg b.wt./day); group 3 (25 mg OP/kg b.wt./day); group 4 (200 mg
CAE/kg b.wt./day); group 5 (CAE 2 h before BPA administration); and group 6 (CAE 2 h
before OP administration). BPA- and OP-exposed groups showed insignificant elevation in
the final body weight; weight gains and significant reduction only in the relative kidneys
weight. Also, BPA and OP exposure resulted in significant increase in serum urea, creatinine
and kidney, brain, testicular malondialdehyde (MDA) levels. Significant reduction in tissues
reduced glutathione (GSH) contents; catalase (CAT) and superoxide dismutase (SOD) activities
were also recorded in BPA and OP exposed animals compared to the control vehicle
group. Pretreatment with CAE 2 h either before BPA or OP administration ameliorated the
BPA- and OP-induced body weight; weight gains and relative organs weight changes and
biochemical adverse effects. CAE pretreatment also protected against the recorded pathological
changes in kidney, brain and testis. In conclusion, CAE could ameliorate the oxidative
toxic effects of BPA and OP indicating its protective antioxidant effect.