چکیده (انگلیسی):

Objective: To assess the histoarchitecture of the maternal liver and kidney as influenced
by selenium supplementation within the periconception period and to determine which of
the periconception stages of selenium intake is most favorable of the liver and kidney.
Methods: Thirty-six 7-week-old female mice were divided into four groups where all
groups were given 6.0 g of food pellets per day. Un-supplemented group (U) received no
selenium in the food pellet, Pre-gestation supplemented group (P) was given 3.0 mg
selenium/d for 21 d, Pre-gestation to Gestation supplemented group (PG) was given
3.0 mg selenium/d for 37 d, and Gestation supplemented group (G) was given 3.0 mg
selenium/d for 16 d only.
Results: The occurrences of vacuolated hepatocytes and congested central veins in the
liver were observed. The P and the G groups incurred the lowest and highest percent
occurrence, respectively, of murine mothers that exhibited presence of vacuolated hepatocytes.
The mean percent occurrence of congested central veins did not significantly
vary among groups. The occurrences of shrunken and swollen glomeruli were observed
in the kidney. The mean percent occurrence of shrunken glomeruli showed that P and G
groups were significantly lower than those of U and PG groups. The mean percent occurrences
of swollen glomeruli did not vary significantly among groups.
Conclusion: The histological analyses of the liver and the kidney obtained from different
stages of periconception indicate that selenium supplementation would be best during
pregestation stage.