چکیده (انگلیسی):

Giant condyloma acuminatum (GCA), originally described by Buschke and Loewenstein
in 1925 as a lesion of the penis, is more rarely seen in the anorectum and is characterized
by clinical malignancy in the face of histologic benignity; however, malignant
transformation to frankly invasive squamous-cell carcinoma has been described in about
one-third of patients. In addition, malignant transformation has been reported in patients
with "ordinary" condylomata acuminata. Human papillomavirus, known to cause condylomata
acuminata, is also known to induce these tumors and was found in 96% of 63 cases reviewed
in the last 10 years. These lesions have a propensity for recurrence and a likelihood of malignant
transformation, and lead to significant mortality. Therefore, early and radical R0 excision,
along with vigilant follow-up, provides the hope for cure. Conservative and/or
multimodal therapy has been reported in a few cases, but its effect is not yet proved. The
authors report one case of GCA; in addition, they reviewed the literature over the last 10
years and compared with previous reviews.