چکیده (انگلیسی):

Introduction: Male breast cancer is extremely rare with an incidence of less than 1% of all breast cancers.
Literature reports a peak of incidence at roughly 71 years of age. Management currently follows the same
clinical pathways as female breast cancer as a general rule.
Methods: A retrospective search for all patients who were referred and diagnosed with male breast
cancer at our centre was undertaken. Patients notes were then explored for demographics, histological
staging, multidisciplinary team meeting outcome and treatment.
A literature search including the search terms ‘Male Breast Cancer AND Surgery’ or ‘Male Breast Cancer
AND Experience’ were used. Non English language articles, or those without abstracts were excluded.
Results: Seven patients were reviewed over 3 years (2006e2009). Mean agea was 69 years and mean
lesion size was 15 mm. Histology was invasive ductal carcinoma for all patients. All patients were ER
receptor positive. Two patients were HER2 positive. Five patients were offered mastectomy. One patient
refused treatment. In follow up at 36 months there were 3 recurrences. 1 patient was lost to follow up.
There were 3 mortalities.
The literature search identified 72 articles. Articles were subdivided into those that discussed the surgical
management of male breast cancer (n ¼ 8), articles that discussed male breast cancer as podium presentations
or posters with no full text article publication (n ¼ 13) and finally full text publications of case
experience of male breast cancer (n ¼ 21).
Discussion: We report a series of seven cases of male breast cancer encountered over three years,
evaluating patient demographics as well as treatment and outcomes. In our series patients were
managed with mastectomy. New evidence is questioning the role of mastectomy against breast
conserving surgery in male patients. Furthermore there is a lack of reporting infrastructure for national
data capture of the benefits of surgical modalities. Literature review highlights the varied clinical
experience between units that remains reported as podium presentation but not published. The
establishment of an online international reporting registry would allow for efficient analysis of surgical outcomes to improve patient care from smaller single centres. This would facilitate large scale meta
analysis by larger academic surgical centres.