چکیده (انگلیسی):

Diabetes mellitus (DM) is a group of metabolic disorders characterized by chronic
hyperglycemia resulting from relative or absolute insulin deficiency with or without insulin resistance.
As anxiolytics may have influence on glycemic control in diabetics, the present study was conducted
to investigate the possible influence of buspirone in streptozotocin-induced DM and its
possible interactions with rosiglitazone, an insulin sensitizer. Diabetes was induced by streptozotocin
(50 mg/kg i.p.). Rats were classified into five groups namely: normal control, diabetic control,
rosiglitazone (10 mg/kg p.o.), buspirone (20 mg/kg i.p.) or combination of both rosiglitazone and
buspirone, respectively. All groups received daily treatments for 2 weeks after induction of DM
including the normal group which received 1% Tween 80. There was no significant interaction
between rosiglitazone and buspirone on the levels of serum glucose, insulin and C-peptide or liver
glycogen content. Similarly, no interaction was observed between rosiglitazone and buspirone on
oxidative stress parameters including serum malondialdehyde and blood glutathione levels or blood
superoxide dismutase activity. In conclusion, the present study revealed that co-administration of buspirone with rosiglitazone does not produce serious reactions and buspirone can be safely
administered as an anxiolytic in diabetic patients treated with rosiglitazone.