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تاریخ امروز
جمعه, ۱۰ فروردین

ماگوت تراپی برای زخم های مزمن: همگروهی گذشته نگر و یک فرا آنالیز

Maggot therapy for chronic ulcer: A retrospective cohort and a meta-analysis

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ورودعضویت
اطلاعات مجله asian journal of surgery 2015 http://www.e-asianjournalsurgery.com
سال انتشار 2013
فرمت فایل PDF
کد مقاله 6677

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چکیده (انگلیسی):

Background/Objective: Maggot wound therapy (MWT) has been used in various
wounds including diabetic foot ulcers, venous leg ulcers, pressure ulcers, and acute surgical
wounds. However, the efficacy of MWT therapy has been controversial. We therefore conducted
a cohort study and a meta-analysis to assess MWT effects.
Methods: A retrospective cohort study was performed in diabetic foot ulcer (DFU) patients who
were treated with MWT or conventional wound therapy (CWT) in Thailand. The Kaplan-Meier
curve was applied to estimate the healing probability. A meta-analysis was performed to pool
our study with four previous cohort studies identified from Medline and Scopus.
Results: The estimated incidence of wound healing was 5.7/100 (95% CI: 4.49, 7.32) patientsweek,
and the median time to healing was 14 weeks. The hazard ratio (HR) of wound healing
was 7.87 times significantly higher in the MWT than the CWT (p < 0.001) after adjusting for
duration and size of ulcers, ankle brachial index (ABI), and glycated hemoglobin (HbA1c).
Meta-analysis was applied and suggested that the treatment effects were moderately heterogeneous
{Chi-square Z 6.18 [degrees of freedom (d.f.) Z 4]; p Z 0.186; I2 Z 35.2%}, with the
pooled risk ratio (RR) of 1.77 [95% confidence intervals (CI) Z 1.01, 3.11], i.e., the chance of
wound healing was 20% significantly higher with MWT than CWT. The average costs of treatment in patients with DFU were lower in the MWT group than in the CWT group, with medians
of US$292.82 and US$490, respectively.
Conclusion: Our evidence suggests that MWT is significantly better for wound healing and more
cost-effective than CWT. An updated meta-analysis or large scale randomized controlled trial
(RCT) is required to confirm this effect

کلمات کلیدی مقاله (فارسی):

زخم مزمن، جراحت مزمن، ماگوت، درمان جراحت با ماگوت، درمان زخم

کلمات کلیدی مقاله (انگلیسی):

chronic ulcer; chronic wound; maggot; maggot wound therapy; wound therapy

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