چکیده (انگلیسی):

The objective of this work was to design a
mucoadhesive tablet with a potential use in the
treatment of oral candidosis. A 2-layered tablet
containing nystatin was formulated. Lactose CD (direct
compression), carbomer (CB), and
hydroxypropylmethylcellulose (HPMC) were used as
excipients. Tablets were obtained through direct
compression. Properties such as in vitro mucoadhesion,
water uptake, front movements, and drug release were
evaluated. The immediate release layer was made of
lactose CD (100 mg) and nystatin (30 mg). The
CB:HPMC 9:1 mixture showed the best mucoadhesion
properties and was selected as excipient for the
mucoadhesive polymeric layer (200 mg). The
incorporation of nystatin (33.3 mg) in this layer affected
the water uptake, which, in turn, modified the erosion
front behavior. Nystatin showed a first-order release.
The polymeric layer presented an anomalous kinetic ( n
= 0.82) when this layer was individually evaluated. The
mucoadhesive tablet formulated in this work releases
nystatin quickly from the lactose layer and then in a
sustained way, during approximately 6 hours, from the
polymeric layer. The mixture CB:HPMC 9:1 showed
good in vitro mucoadhesion. A swelling-diffusion process
modulates the release of nystatin from this layer. A non-
Fickian (anomalous) kinetic was observed.