چکیده (انگلیسی):

Objective: To investigate various therapeutic effects of medicinal plant Ziziphus jujube
(Z. jujube), such as antibacterial, antiviral, anticancer, anti-inflammatory and antioxidant
properties. Methods: The present study was conducted to assess the beneficial effects of
aqueous extract of Z. jujube fruit on the proliferation of breast cancer cells by MTT assay
and the antioxidant by FRAP, haematological and biochemical alterations caused by NMUinduced
mammary carcinogenesis in rats. The rats were divided into five groups, control group
A (n=10), Z. jujube control group B (n=10), NMU control group C (n=15), Z. jujube treatment
group D (n=15) and Z. jujube prevention group E (n=15). At the end of the experimental
period, all the animals were euthanized and blood was collected by heart puncture. Results:
The Z. jujube revealed a dose- and time-dependent cytotoxic effect against an MDA-MB-
468 cell line and its treatment significantly (P<0.05) increased the total antioxidant capacity
when compared to the NMU control group C. Z. jujube exhibited a preventive effect against
anaemia, lymphocytosis and neutrophilia in group D and group E, when compared to group
C. Biochemical analyses showed normal levels of enzymes of the liver in the Z. jujube treated
groups: B, D and E rats, whereas NMU control group C showed significant (P<0.05) decreases
in ALT, AST, albumin and total protein levels, and significant (P<0.05) increases in ALP and
LDH. Conclusions: These findings indicate that the Z. jujube ameliorates the adverse effects of
NMU carcinogenesis and could be useful for treating mammary tumours in humans.