چکیده (انگلیسی):

This investigation was undertaken to evaluate ethanolic extract of Cordia macleodii leaves
for possible antioxidant and hepatoprotective potential. Antioxidant activity of the extracts was evaluated
by four established, in vitro methods viz. 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging
method, nitric oxide (NO) radical scavenging method, iron chelation method and reducing
power method. The extract demonstrated a significant dose dependent antioxidant activity comparable
with ascorbic acid. The extract was also evaluated for hepatoprotective activity by carbon tetrachloride
(CCl4) induced liver damage model in rats. CCl4 produced a significant increase in levels of
serum glutamate pyruvate transaminase (GPT), serum glutamate oxaloacetate transaminase
(GOT), Alkaline Phosphatase (ALP) and total bilirubin. Pretreatment of the rats with ethanolic
extract of C. macleodii (100, 200 and 400 mg/kg po) inhibited the increase in levels of GPT, GOT,
ALPand total bilirubin and the inhibition was comparable with Silymarin (100 mg/kg po). The present
study revealed that C. macleodii leaves have significant radical scavenging and hepatoprotective activities.