چکیده (انگلیسی):

Cardiotoxicity is one of the major side effects of anthracycline antibiotics. Most studies
implicated increased oxidative stress as the major determinant of doxorubicin (DOX) cardiotoxicity.
The aim of the current investigation was to study the possible cardioprotective effect of Stachys
schimperi Vatke (family Lamiaceae) on DOX-induced cardiotoxicity in rats based on biochemical
and histopathological parameters. The phenolic profile of the methanol extract was determined qualitatively
by HPLC. Isoscutellarein 7-O-[200-O-(60 0 0-acetyl)-b-D-allopyranosyl]-b-D-glucopyranoside
(compound 1) was isolated and identified from EB fraction as a major constituent for the first time
from this Stachys species. The methanolic extract and the combined EtOAc and n-butanol fractions
(EB) as well as compound 1 showed prominent free radical scavenging activity when assessed by the
DPPH method. The methanolic extract showed moderate protection against DOX-induced
alteration in cardiac oxidative stress markers; GSH and MDA, and cardiac serum markers;
CK-MB and LDH activities. Additionally, histopathological study denoted mild protection against
DOX-induced cardiotoxicity.