چکیده (انگلیسی):

Emulgels have emerged as a promising drug delivery system for the delivery of hydrophobic
drugs. The objective of the study was to prepare emulgel of mefenamic acid, a NSAID, using
Carbapol 940 as a gelling agent. Mentha oil and clove oil were used as penetration enhancers. The
emulsion was prepared and it was incorporated in gel base. The formulations were evaluated for
rheological studies, spreading coefficient studies, bioadhesion strength, skin irritation studies,
in vitro release, ex vivo release studies, anti-inflammatory activity and analgesic activity. Formulation
F2 and F4 showed comparable analgesic and anti-inflammatory activity when they compared
with marketed diclofenac sodium gel. So, it can be concluded that topical emulgel of mefenamic
acid posses an effective anti-inflammatory and analgesic activity.