چکیده (انگلیسی):

Objectives: To investigate the prevalence of urinary tract infection among patients at
Messalata Central Hospital, Libya, to identify the causative bacteria, and to explore their
resistance pattern to antimicrobials.
Methods: A total number of 1 153 urine samples were collected from patients, who
attended daily to Messalata Central Hospital, Libya, in a study extended for one year.
Antimicrobial susceptibility testing and isolates typing were done using Phoenix BD (BD
diagnostic). Resistance was confirmed manually using agar disk diffusion method.
Results: Of the 1 153 urine samples tested, 160 (13.9%) samples were positive, from
which 17 different, solely Gram negative, uropathogens were identified. Escherichia coli
were the most prevalent (55.6%) bacteria, followed by Klebsiella pneumoniae subspecies
pneumoniae (16.3%), Proteus mirabilis (6.3%), Pseudomonas aeruginosa (5.6%),
Enterobacter cloacae and Klebsiella oxytoca (2.5%, each), Citrobacter koseri and
Providencia rettgeri (1.9%, each), Acinetobacter baumannii, Enterobacter aerogenes and
Proteus vulgaris (1.3%, each), and Aeromonas caviae, Citrobacter freundii, Cronobacter
sakazakii, Enterobacter amnigenus biogroup 2, Pseudomonas putida and Serratia marcescens
(0.6%, each). The isolated uropathogens showed increased levels of resistance
ranged from 10.5% to 64.5%, with an overall resistance of 28.9%. Amikacin was the
most effective antimicrobial followed by Imipenem and Meropenem (0%, 0.6% and 2.5%
resistance, respectively); while, Cephalothin and Ampicillin were the least (80.6% and
90.0% resistance, respectively) effective.
Conclusions: The obtained results emphasized the emergence of highly resistant bacteria
to most of tested antimicrobials and raise the alarm for physicians to change their
treatment pattern depending on antimicrobial susceptibility results.