چکیده (انگلیسی):

Background: In Graves’ disease, because a thyroid tends to have extreme vascularity,
the amount of intraoperative blood loss (AIOBL) becomes significant in some cases.
We sought to elucidate the predictive factors of the AIOBL.
Methods: A total of 197 patients underwent thyroidectomy for Graves’ disease between 2002 and
2012. We evaluated clinical factors that would be potentially related to AIOBL retrospectively.
Results: The median period between disease onset and surgery was 16 months (range: 1e480
months). Conventional surgery was performed in 125 patients, whereas video-assisted surgery
was performed in 72 patients. Subtotal and near-total/total thyroidectomies were performed in
137 patients and 60 patients, respectively. The median weight of the thyroid was 45 g (range:
7.3e480.0 g). Univariate analysis revealed that the strongest correlation of AIOBL was noted with
the weight of thyroid (p < 0.001). Additionally, AIOBL was correlated positively with the period between
disease onset and surgery (p < 0.001) and negatively with preoperative free T4 (p < 0.01).
Multivariate analysis showed that only the weight of the thyroid was independently correlated with
AIOBL (p < 0.001). Four patients (2.0%) needed blood transfusion, including two requiring autotransfusion,
whose thyroids were all weighing in excess of 200 g. The amount of drainage during
the initial 6 hours and days until drain removal was correlated positively with AIOBL (p < 0.001,
each). Occurrences of postoperative complications, such as recurrent laryngeal nerve palsy or hypoparathyroidism,
and postoperative hospital stay were not correlated with AIOBL.
Conclusion: A huge goiter presented as a predictive factor for excessive bleeding during surgery for
Graves’ disease, and preparation for blood transfusion should be considered in cases where thyroids
weigh more than 200 g.