چکیده (انگلیسی):

Zika virus (ZIKV) was discovered more than half a century ago, recently it has gained
unprecedented attention by the global health community. Until 2007, only 14 cases of
human ZIKV infections were reported around the globe, while during the current
outbreak, estimated cases mounted to approximately 1.5 million in Brazil alone, the virus
was disseminated to wider South-American territories and travel-associated ZIKV infections
were reported in USA, Europe and recently in China. ZIKV infections remain
asymptomatic in approximately 80% of the individuals, and no anti-viral treatments were
recommended. Yet, neurological complications associated with the infections, such as
infant microcephaly and Guillain–Barre syndrome are major cause of the concern. ´
Although, based on small numbers of cases, existing evidence strongly supports an
exclusive link of viral infection and observed neurological complications. However,
much work remains to assign exact numbers of complications caused by ZIKV.
Regarding its structural attributes ZIKV shows remarkable resemblance with dengue
virus and West-Nile virus. Despite, genomes of different ZIKV strains have already been
decoded; role of the viral components in infection process and particularly pathogenesis
of the disease remain widely unclear. In vulnerable areas, most viable strategy to ensure
public health safety is vector control and enhanced public awareness about the transmission
of the disease.