چکیده (انگلیسی):

Objective: To evaluate the effect of hydroethanolic extract of yacon on the hyperglycemia
induced by streptozotocin (STZ) in neonatal rats.
Methods: Wistar rats aged two days old received an intraperitoneal injection of STZ
(160 mg/kg); after seven weeks, glycosuria was determined and animals with glucose
levels above 250 mg/dL were included in the study. Groups of diabetic and non-diabetic
rats were treated orally with yacon extract at a dose of 400 mg/kg/d for 14 d. Tests were
made for phytochemical characterization, glucose tolerance and toxicity.
Results: The results showed that treatment with the extract reduced the glucose levels of
fed diabetic rats and did not change the glucose levels of fasting diabetic and normal rats.
Additionally, also it was observed that treatment with the extract reduced blood glucose
levels of diabetic rats during the oral and intravenous glucose tolerance tests. There was
no change in body weight, liver enzymes or mortality with yacon extract treatment. The
phytochemical screening revealed the presence of caffeic acid, chlorogenic acid, ferulic
acid and gallic acid.
Conclusions: The data suggest that yacon extract reduces hyperglycemia, possibly by
improving insulin sensibility through its phytochemicals constituents (phenolic
compounds).