چکیده (انگلیسی):

The high prevalence of Japanese cedar pollinosis in Japan is associated with a negative impact on the
quality of life of patients, as well as significant loss of productivity among the workforce in early spring,
thus representing a serious social problem. Furthermore, the prevalence is increasing, and has risen by
more than 10% in this decade. Cry j 1 and Cry j 2 were identified as the major allergens in Japanese cedar
pollen (JCP), and in 2004, the existence of other major and minor allergens were revealed by a combination
of two-dimensional electrophoresis and immunoblotting analysis. Allergenome analysis identified
a chitinase, a lipid transfer protein, a serine protease, and an aspartic protease as novel IgE-reactive
allergens in patients with JCP allergy. Thaumatin-like protein (Cry j 3) was shown to be homologous
to Jun a 3, a major allergen from mountain cedar pollen. Isoflavone reductase-like protein was also
characterized in a study of a JCP cDNA library. The characterization of component allergens is required to
clarify the sensitizer or cross-reactive elicitor allergens for component-resolved diagnosis (CRD).
Increasing evidence from numerous clinical trials indicates that CRD can be used to design effective
allergen-specific immunotherapy. In this review, we summarize the eight characterized JCP allergens and
discuss the impact of CRD and characterization of novel allergens on allergen-specific immunotherapy.