چکیده (انگلیسی):

The purpose of this research was to develop and evaluate a
multiparticulate system of chitosan hydrogel beads exploiting
pH-sensitive property and specific biodegradability for
colon-targeted delivery of satranidazole. Chitosan hydrogel
beads were prepared by the cross-linking method followed
by enteric coating with Eudragit S100. All formulations
were evaluated for particle size, encapsulation efficiency,
swellability, and in vitro drug release. The size of the beads
was found to range from 1.04 ± 0.82 mm to 1.95 ± 0.05 mm.
The amount of the drug released after 24 hours from the
formulation was found to be 97.67% ± 1.25% in the presence
of extracellular enzymes as compared with 64.71% ±
1.91% and 96.52% ± 1.81% release of drug after 3 and
6 days of enzyme induction, respectively, in the presence
of 4% cecal content. Degradation of the chitosan hydrogel
beads in the presence of extracellular enzymes as compared
with rat cecal and colonic enzymes indicates the potential of
this multiparticulate system to serve as a carrier to deliver
macromolecules specifically to the colon and can be offered
as a substitute in vitro system for performing degradation
studies. Studies demonstrated that orally administered chitosan
hydrogel beads can be used effectively for the delivery
of drug to the colon.