چکیده (انگلیسی):

Objective: To assess antifertility activity of hydroalcoholic extract of Cordia dichotoma G
Forst. (C. dichotoma) leaves, which are traditionally used to produce sterility among the tribal
women through its abortificient activity. Methods: Acute toxicity study was carried out in
adult albino rats. The antifertility activity of extract at two dose level (200 and 400 mg/kg,
orally) was evaluated in two experimental animal models i.e. anti-implantation and estrogenic/
antiestrogenic activity in female rats by observing number of implants, vaginal cornification,
body weight, uterus weight and biochemical investigation. Results: The extract was found
to be safe up to dose of 2 000 mg/kg body weight when administered orally. A good antiimplantation
(81.22%) activity in female rats was observed at the tested dose levels (200 and
400 mg/kg, orally). The extract further showed more significant (P<0.01) increase in uterine
weight and significant change in biochemical parameters in immature rats. Simultaneous
administration of extract along with ethinyl estradiol showed significant estrogenic activity. Conclusion: The results suggest that hydro alcoholic extract of C. dichotoma leaves possess
significant antifertility activity, which is consistent with the literature report in folk medicine
of this plant in fertility regulation.