چکیده (انگلیسی):

Objective: To explore effect of gum arabic (GA) on semen quality and oxidative stress
capacity of alloxan induced diabetes rats.
Methods: In this study, male Sprague–Dawley rats were divided into 3 groups (n = 20 of
each): control group, diabetic group which were injected with alloxan, and diabetic group
which was given 10% GA in the form of drinking water for 10 weeks. The effect of GA
on testicular oxidative stress and sperm quality were investigated. Testicular antioxidant
was detected by the measurement of antioxidant enzymes, malondialdehyde in testis
tissue. Moreover, plasma lipids, testis histopathological changes and oxidative stress
related genes mRNA were evaluated.
Results: The treatment of GA significantly (P < 0.05) increased semen quality compared
the diabetic and control groups. Similarly, the treatment of GA significantly (P < 0.05)
increased the activities of catalase, superoxide dismutase and glutathione peroxidase
compared to diabetic and control groups. The treatment of GA significantly (P < 0.05)
decreased testis malondialdehyde, plasma total cholesterol, low-density lipoprotein
cholesterol and triglyceride concentrations, whereas increased high-density lipoprotein
cholesterol concentrations compared to the diabetic groups. Glutathione peroxidase and
superoxide dismutase mRNA expression were significantly (P < 0.05) increased in GA
treated group compared to diabetic and control groups. All testes of diabetic rats displayed
obvious degeneration; whereas slight degeneration was seen in GA treated rats
when compared to diabetic control group.
Conclusion: Our findings imply that GA may protect testis via enhancement of antioxidant
capacity, it may be useful to meliorate the diabetic fertility complications.