چکیده (انگلیسی):

The purpose of this investigation was to study the antiinflammatory
activities of both glycerrhitinic acid (GA)
and the aqueous licorice extract (ALE) in comparison with
diclofenac sodium (DS) (10 mg/kg), using the carrageenan-
induced paw edema model in male albino rats. In
addition, the anti-ulcer activities of ALE, famotidine (FT),
and a combination of ALE and FT using indomethacininduced
ulceration technique in rat stomach were investigated.
Conventional DS tablets containing GA, as well as
DS chewable tablets containing either GA or ALE with different
tastes were prepared. Also, rapidly disintegrating FT
tablets were prepared using direct compression and camphor
sublimation methods. ALE or GA produced significant
anti-inflammatory activity similar to DS, and when
taken concomitantly, there is no possible antagonism. The
anti-ulcer activity of licorice was found to be similar to that
of FT in indomethacin-induced ulceration technique in rat
stomach. Combination therapy of both FT and licorice
showed higher anti-ulcer activity than either of them alone.
Generally, tablets containing the crosslinked sodium carboxymethyl
cellulose (AcDisol) showed more rapidly disintegrating
effect than those including Sodium starch glycolate
(Primojel). The oral disintegration was very rapid
for all the tested formulations. Also, the amount of FT
absorbed from the oral cavity was nearly 9 from 10 mg theoretically
present in each formula. It could be concluded
that both GA and ALE have anti-inflammatory activity
comparable with DS. It may be recommended to add ALE
to either FT or diclofinac for more effective anti-inflammatory
or anti-ulcer formulations, respectively.