چکیده (انگلیسی):

Hemodynamic factors such as velocity distribution, pressure gradient and wall shear stress are thought to play an important role in the prognosis of symptomatic carotid occlusion. Although there are many studies about modeling the blood flow behavior in carotid, hemodynamic characteristics of blood flow in a stenosed carotid artery is still debatable. In this study a three-dimensional (3D) model of a symmetric stenosed common carotid artery (CCA) is developed and the simulation results of it are compared to the experimental data where subsequent agreement is confirmed. To study the accuracy of two-dimensional (2D) axisymmetric model, the result of it is compared to the result of the 3Dmodel.Twonon-Newtonian rheological models, namely Carreau and modified Power-law, as well as Newtonian model are used to realize the hemodynamical differences of 2D-axisymmetric and 3D models in pulsatile blood flow. Comparing the 3D simulated
results with 2D-axisymmetric modeling results that were published in recent years indicates that the assumption of 2Daxisymmetric model cannot adequately predict the velocity profiles even for a symmetric stenotic artery. Although a symmetric stenotic artery is considered, the results indicate a nonsymmetric flow in poststenosis region that is detected by the presence of extensive secondary flows particularly at diastole. The existence of secondary flows that can only be detected in 3D modeling is the main reason for the differences in hemodynamic factors in 3D and 2D results.