چکیده (انگلیسی):

Recently, there has been great interest in bioreductive drugs
for the treatment of cancer. Bioreductive drugs are designed
to take advantage of the unique features of solid tumors, especially
oxygen tension and the overexpression of certain reductase
enzymes.1 Of the several reductase enzymes, DTD
(NAD(P)H: quinone oxidoreductase) is excessively found
in solid tumors. Using NADPH and NADH as an electron
donor, DTD is capable of reducing quinone-type compounds
to DNA damaging species.2
RH1 is a water-soluble diaziridinyl benzoquinone derivative
that has been shown to have preferential activity against human
tumor cell lines that express high levels of the 2-electron
reductase DTD.3