چکیده (انگلیسی):

Objectives: Chloroquine (CQ), after 67 years of use in Haiti, is still part of the official treatment policy for malaria.
Several countries around the world have used CQ in the past due to its low incidence of adverse events,
therapeutic efficacy, and affordability, but were forced to switch treatment policy due to the development of
widespread CQ resistance. The purpose of this paper was to compile literature on malaria treatment policies and
antimalarial drug efficacy in Haiti over 67-year period.
Methods: A systematic review of PubMed, Web of Science, and the Armed Forces Pest Management Board, was
conducted to find pertinent documents on national malaria treatment policies and antimalarial drug efficacy
studies in Haiti between 1955 and 2012. A total of 329 citations and abstracts were reviewed independently by two
researchers, of which thirty three met the final inclusion criteria of studies occurring in Haiti between 1955 and
2012 which specifically discuss malaria treatment policies and drug efficacy.
Results: Results suggest that CQ has been the predominant antimalarial drug in use from 1955 to 2012. In 2010
single dose primaquine (PQ) was added to the national treatment policy, however it is not clear whether this new
policy has been put into practice.
Conclusions: Although no widespread CQ resistance has been reported, some studies have detected low