چکیده (انگلیسی):

About eleven substituted (E)-3-(5-bromothiophen-2-yl)-1-phenylprop-2-en-1-ones have been synthesized by Crossed-Aldol condensation using simple stirring of 5-bromo-2-thiophen aldehyde and various substituted acetophenones at room temperature. The obtained yields of this condensation was more than 89%. They are characterized by their analytical, UV, FT-IR and NMR spectral data. The antimicrobial activities of all synthesized chalcones have been evaluated by Bauer-Kirby disc diffusion method using gram positive and gram negative bacterial and fungal strains. From the mm of zone of inhibition values the anti-bacterial and antifungal activities of all ketones have been discussed.