چکیده (انگلیسی):

Objective: To evaluate the reproductive toxicity of aqueous wood ash extract of Azadirachta
indica (A. indica) in male albino mice.
Methods: Four different dose levels of 0, 5, 50 and 100 mg/kg body weight were
administered to 20 male mice, with five mice per group for seven days that were sacrificed
35 days thereafter. Gonadosomatic index, sperm motility, sperm count, sperm
morphology, serum follicle stimulating hormone (FSH), leuitinizing hormone (LH) and
testosterone assay, and histopathology of testes were carried out.
Results: Though no toxic effect on testicular weight, FSH, LH and testosterone
(P > 0.05), significant decrease in sperm motility, live/dead sperm and sperm count, with
significant increase of abnormal sperm were recorded (P < 0.05). Dose dependent histopathological
damage of testes was obtained (P < 0.05).
Conclusion: Aqueous wood ash extract of A. indica have damaging effects on sperms
and testicular tissues, which could impair reproduction.